Journal of Blood Medicine (May 2023)

Platelet Selectin Levels in Patients with Cerebral Venous Sinus Thrombosis: Preliminary Findings

  • Zenobia E,
  • Lailiyya N,
  • Dian S,
  • Juli C,
  • Nugraha Hermawan A,
  • Amalia L

Journal volume & issue
Vol. Volume 14
pp. 359 – 365

Abstract

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Eswi Zenobia, Nushrotul Lailiyya, Sofiati Dian, Cep Juli, Asep Nugraha Hermawan, Lisda Amalia Neurology Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Lisda Amalia, Neurology Department, Faculty of Medicine, Universitas Padjadjaran, Jl. Eykman 38 Bandung, Bandung, 40161, Indonesia, Email [email protected]: Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease with an estimated annual incidence of 3– 4 cases per 1 million population with an 8% mortality rate caused by hypercoagulable conditions and hyper aggregation and also Platelet Selectin (P-Selectin) as one of coagulation biomarker for both of them. This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.Objective: This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.Methods: This is a descriptive observational study on patients ≥ 18 years old diagnosed with CVST at the Neurology outpatient polyclinic of RSUP Dr. Hasan Sadikin Bandung for March-May 2022. All samples that meet the inclusion criteria will be included as research subjects.Results: There were 55 research subjects with a median age of 48 (range 22– 69 years), the majority were women (80%), the most complaints were headaches (92.7%), the majority onset was chronic (96.4%) with a length of treatment ≥ 12 months (61.8%). P-selectin levels were found to increase in the group of subjects with subacute onset (mean 5.20 ± 2.977), infectious etiology (mean 5.26 ± 3.561), duration of treatment < 3 Months (mean 3.79 ± 3.065), history of hyper aggregation (mean 3.89± 2.805), hypercoagulation (mean 3.50± 2.719), increased D-dimer (mean 3.93± 2.710), normal fibrinogen (mean 3.38± 2.693), and in the group with multiple affected sinuses (mean 6.08± 2.681).Conclusion: P-selectin could be a diagnostic marker for hyper aggregation and hypercoagulable state in patients with CVST, but it still needs further research to prove it.Keywords: Cerebral Venous Sinus Thrombosis, P-selectin, platelet hyperaggregation, hypercoagulation

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