Pentraxin-3 Modulates Osteogenic/Odontogenic Differentiation and Migration of Human Dental Pulp Stem Cells

Yeon Kim; Joo-Yeon Park; Hyun-Joo Park; Mi-Kyoung Kim; Yong-Il Kim; Hyung  Joon Kim; Soo-Kyung Bae; Moon-Kyoung Bae

doi:10.3390/ijms20225778

International Journal of Molecular Sciences (Nov 2019)

Pentraxin-3 Modulates Osteogenic/Odontogenic Differentiation and Migration of Human Dental Pulp Stem Cells

Yeon Kim,
Joo-Yeon Park,
Hyun-Joo Park,
Mi-Kyoung Kim,
Yong-Il Kim,
Hyung Joon Kim,
Soo-Kyung Bae,
Moon-Kyoung Bae

Affiliations

Yeon Kim: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Joo-Yeon Park: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Hyun-Joo Park: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Mi-Kyoung Kim: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Yong-Il Kim: Department of Orthodontics, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Hyung Joon Kim: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Soo-Kyung Bae: Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan 50610, Korea
Moon-Kyoung Bae: Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea

DOI: https://doi.org/10.3390/ijms20225778
Journal volume & issue: Vol. 20, no. 22
p. 5778

Abstract

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Pentraxin-3 (PTX3) is recognized as a modulator of inflammation and a mediator of tissue repair. In this study, we characterized the role of PTX3 on some biological functions of human dental pulp stem cells (HDPSCs). The expression level of PTX3 significantly increased during osteogenic/odontogenic differentiation of HDPSCs, whereas the knockdown of PTX3 decreased this differentiation. Silencing of PTX3 in HDPSCs inhibited their migration and C-X-C chemokine receptor type 4 (CXCR4) expression. Our present study indicates that PTX3 is involved in osteogenic/odontogenic differentiation and migration of HDPSCs, and may contribute to the therapeutic potential of HDPSCs for regeneration and repair.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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