Nature Communications (May 2019)

The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)

  • Michael A. Estrella,
  • Jin Du,
  • Li Chen,
  • Sneha Rath,
  • Eliza Prangley,
  • Alisha Chitrakar,
  • Tsutomu Aoki,
  • Paul Schedl,
  • Joshua Rabinowitz,
  • Alexei Korennykh

DOI
https://doi.org/10.1038/s41467-019-10125-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and NADPH, providing a direct link to metabolic regulation.