Proceedings
(Aug 2019)
In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors
L. M. Viranga Tillekeratne,
Ayad Ayad Al-Hamashi,
Samkeliso Dlamini,
William Taylor,
Radhika Koranne,
Mary Kay Pflum,
Ahmed T. Negmeldin,
Joseph Knoff
Affiliations
L. M. Viranga Tillekeratne
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
Ayad Ayad Al-Hamashi
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
Samkeliso Dlamini
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
William Taylor
Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
Radhika Koranne
Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
Mary Kay Pflum
Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
Ahmed T. Negmeldin
Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
Joseph Knoff
Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
DOI
https://doi.org/10.3390/proceedings2019022063
Journal volume & issue
Vol. 22,
no. 1
Abstract
Read online
Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. [...]
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