Nature Communications (Sep 2016)

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

  • Takahito Miyake,
  • Saki Nakamura,
  • Meng Zhao,
  • Kanako So,
  • Keisuke Inoue,
  • Tomohiro Numata,
  • Nobuaki Takahashi,
  • Hisashi Shirakawa,
  • Yasuo Mori,
  • Takayuki Nakagawa,
  • Shuji Kaneko

DOI
https://doi.org/10.1038/ncomms12840
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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The transient receptor potential ankyrin 1 (TRPA1) is a cation channel that is involved in nociceptive pain sensing. Here, the authors show that hydroxylation of a proline in the N terminus of TRPA1 renders it sensitive to reactive oxygen species resulting from noxious cold.