Nature Communications (Jul 2017)

Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons

  • Kalpana Makhijani,
  • Brandy Alexander,
  • Deepti Rao,
  • Sophia Petraki,
  • Leire Herboso,
  • Katelyn Kukar,
  • Itrat Batool,
  • Stephanie Wachner,
  • Katrina S. Gold,
  • Corinna Wong,
  • Michael B. O’Connor,
  • Katja Brückner

DOI
https://doi.org/10.1038/ncomms15990
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Hematopoietic sites in theDrosophilalarva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion.