Frontiers in Oncology (Aug 2024)

Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region

  • Ke Huang,
  • Wen-wen Liu,
  • Xiu-wen Chen,
  • Yin-hua Hao,
  • Sen-yuan Luo,
  • Ling-ling Yuan,
  • Yu-gang Huang,
  • Xian-bin Tang

DOI
https://doi.org/10.3389/fonc.2024.1339582
Journal volume & issue
Vol. 14

Abstract

Read online

We illustrated a rare case of malignant solitary fibrous tumor (MSFT) with epithelioid morphology in the occipital region of a 59-year-old female, in which a rare NAB2ex7-STAT6 exon15/16 double fusion subtype was detected by the Next-generation sequencing (NGS) and STAT6 immunohistochemistry (IHC) was diffusely and strongly positively expressed, without recurrence after 20 months of postoperative follow-up. The morphological and molecular genetic aspects and the differential diagnosis are described, and the relevant literature was assessed in order to broaden our understanding and diagnostic capability of this malignancy.

Keywords