Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan
Satoru Kondo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan; Department of Molecular Physiology, Kyushu University, Fukuoka, Japan
Masaki Nomura
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan; Department of Mathematics, Kyoto University, Kyoto, Japan
Sayuri Hatada
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan
Noboru Yamaguchi
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan
Alsayed A Mohamed
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan; Department of Anatomy and Embryology, South Valley University, Qena, Egypt
Fuyuki Karube
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan; Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, Kyotanabe, Japan
Joachim Lübke
Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH/University Hospital Aachen, Aachen, Germany; JARA Translational Brain Medicine, Jülich/Aachen, Germany
Yasuo Kawaguchi
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan
Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. Serial electron micrograph (EMg) reconstructions showed that somatic synapses were larger than dendritic contacts. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition.
