Piperacillin/Tazobactam-Induced Neutropenia: A Case Report

Abstract

Neutropenia, secondary to immune destruction or maturation arrest, is commonly described as an adverse hematological effect of beta-lactam antibiotics. A 29-year-old woman was being treated with piperacillin/tazobactam due to draining heel osteomyelitis. Herein, we present a case of reversible neutropenia occurring on the 25th day of treatment. Neutropenia resolved six days after discontinuation of piperacillin/tazobactam. We think that patients receiving prolonged treatment with piperacillin/tazobactam should be followed cautiously for neutropenia.

Keywords

• Piperacillin
• tazobactam
• neutropenia
• adverse effect