Upgrading ketone synthesis direct from carboxylic acids and organohalides

Rehanguli Ruzi; Kai Liu; Chengjian Zhu; Jin Xie

doi:10.1038/s41467-020-17224-2

Nature Communications (Jul 2020)

Upgrading ketone synthesis direct from carboxylic acids and organohalides

Rehanguli Ruzi,
Kai Liu,
Chengjian Zhu,
Jin Xie

Affiliations

Rehanguli Ruzi: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Kai Liu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Chengjian Zhu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jin Xie: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-020-17224-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Due to their abundance and importance in organic chemistry, development of methods for ketone synthesis is essential. Here, the authors report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of aromatic acids and aryl/alkyl bromides to directly synthesise ketones.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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