eLife (Apr 2021)

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

  • Salwa Naushin,
  • Viren Sardana,
  • Rajat Ujjainiya,
  • Nitin Bhatheja,
  • Rintu Kutum,
  • Akash Kumar Bhaskar,
  • Shalini Pradhan,
  • Satyartha Prakash,
  • Raju Khan,
  • Birendra Singh Rawat,
  • Karthik Bharadwaj Tallapaka,
  • Mahesh Anumalla,
  • Giriraj Ratan Chandak,
  • Amit Lahiri,
  • Susanta Kar,
  • Shrikant Ramesh Mulay,
  • Madhav Nilakanth Mugale,
  • Mrigank Srivastava,
  • Shaziya Khan,
  • Anjali Srivastava,
  • Bhawana Tomar,
  • Murugan Veerapandian,
  • Ganesh Venkatachalam,
  • Selvamani Raja Vijayakumar,
  • Ajay Agarwal,
  • Dinesh Gupta,
  • Prakash M Halami,
  • Muthukumar Serva Peddha,
  • Gopinath M Sundaram,
  • Ravindra P Veeranna,
  • Anirban Pal,
  • Vinay Kumar Agarwal,
  • Anil Ku Maurya,
  • Ranvijay Kumar Singh,
  • Ashok Kumar Raman,
  • Suresh Kumar Anandasadagopan,
  • Parimala Karuppanan,
  • Subramanian Venkatesan,
  • Harish Kumar Sardana,
  • Anamika Kothari,
  • Rishabh Jain,
  • Anupama Thakur,
  • Devendra Singh Parihar,
  • Anas Saifi,
  • Jasleen Kaur,
  • Virendra Kumar,
  • Avinash Mishra,
  • Iranna Gogeri,
  • Geethavani Rayasam,
  • Praveen Singh,
  • Rahul Chakraborty,
  • Gaura Chaturvedi,
  • Pinreddy Karunakar,
  • Rohit Yadav,
  • Sunanda Singhmar,
  • Dayanidhi Singh,
  • Sharmistha Sarkar,
  • Purbasha Bhattacharya,
  • Sundaram Acharya,
  • Vandana Singh,
  • Shweta Verma,
  • Drishti Soni,
  • Surabhi Seth,
  • Sakshi Vashisht,
  • Sarita Thakran,
  • Firdaus Fatima,
  • Akash Pratap Singh,
  • Akanksha Sharma,
  • Babita Sharma,
  • Manikandan Subramanian,
  • Yogendra S Padwad,
  • Vipin Hallan,
  • Vikram Patial,
  • Damanpreet Singh,
  • Narendra Vijay Tripude,
  • Partha Chakrabarti,
  • Sujay Krishna Maity,
  • Dipyaman Ganguly,
  • Jit Sarkar,
  • Sistla Ramakrishna,
  • Balthu Narender Kumar,
  • Kiran A Kumar,
  • Sumit G Gandhi,
  • Piyush Singh Jamwal,
  • Rekha Chouhan,
  • Vijay Lakshmi Jamwal,
  • Nitika Kapoor,
  • Debashish Ghosh,
  • Ghanshyam Thakkar,
  • Umakanta Subudhi,
  • Pradip Sen,
  • Saumya Ray Chaudhury,
  • Rashmi Kumar,
  • Pawan Gupta,
  • Amit Tuli,
  • Deepak Sharma,
  • Rajesh P Ringe,
  • Amarnarayan D,
  • Mahesh Kulkarni,
  • Dhansekaran Shanmugam,
  • Mahesh S Dharne,
  • Sayed G Dastager,
  • Rakesh Joshi,
  • Amita P Patil,
  • Sachin N Mahajan,
  • Abujunaid Habib Khan,
  • Vasudev Wagh,
  • Rakesh Kumar Yadav,
  • Ajinkya Khilari,
  • Mayuri Bhadange,
  • Arvindkumar H Chaurasiya,
  • Shabda E Kulsange,
  • Krishna Khairnar,
  • Shilpa Paranjape,
  • Jatin Kalita,
  • Narahari G Sastry,
  • Tridip Phukan,
  • Prasenjit Manna,
  • Wahengbam Romi,
  • Pankaj Bharali,
  • Dibyajyoti Ozah,
  • Ravi Kumar Sahu,
  • Elapavalooru VSSK Babu,
  • Rajeev Sukumaran,
  • Aiswarya R Nair,
  • Prajeesh Kooloth Valappil,
  • Anoop Puthiyamadam,
  • Adarsh Velayudhanpillai,
  • Kalpana Chodankar,
  • Samir Damare,
  • Yennapu Madhavi,
  • Ved Varun Aggarwal,
  • Sumit Dahiya,
  • Anurag Agrawal,
  • Debasis Dash,
  • Shantanu Sengupta

DOI
https://doi.org/10.7554/eLife.66537
Journal volume & issue
Vol. 10

Abstract

Read online

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92–2.59, <0.0001), use of public transport (1.79, 1.43–2.24, <0.0001), not smoking (1.52, 1.16–1.99, 0.0257), non-vegetarian diet (1.67, 1.41–1.99, <0.0001), and B blood group (1.36, 1.15–1.61, 0.001).

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