Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

Ignacio Benedicto; Guillermo L. Lehmann; Michael Ginsberg; Daniel J. Nolan; Rohan Bareja; Olivier Elemento; Zelda Salfati; Nazia M. Alam; Glen T. Prusky; Pierre Llanos; Sina Y. Rabbany; Arvydas Maminishkis; Sheldon S. Miller; Shahin Rafii; Enrique Rodriguez-Boulan

doi:10.1038/ncomms15374

Nature Communications (May 2017)

Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

Ignacio Benedicto,
Guillermo L. Lehmann,
Michael Ginsberg,
Daniel J. Nolan,
Rohan Bareja,
Olivier Elemento,
Zelda Salfati,
Nazia M. Alam,
Glen T. Prusky,
Pierre Llanos,
Sina Y. Rabbany,
Arvydas Maminishkis,
Sheldon S. Miller,
Shahin Rafii,
Enrique Rodriguez-Boulan

Affiliations

Ignacio Benedicto: Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine
Guillermo L. Lehmann: Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine
Michael Ginsberg: Angiocrine Bioscience, Inc.
Daniel J. Nolan: Angiocrine Bioscience, Inc.
Rohan Bareja: Department of Physiology and Biophysics, Weill Cornell Medicine
Olivier Elemento: Department of Physiology and Biophysics, Weill Cornell Medicine
Zelda Salfati: Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine
Nazia M. Alam: Burke Medical Research Institute
Glen T. Prusky: Department of Physiology and Biophysics, Weill Cornell Medicine
Pierre Llanos: Bioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University
Sina Y. Rabbany: Bioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University
Arvydas Maminishkis: Section of Epithelial and Retinal Physiology and Disease, National Eye Institute, National Institutes of Health
Sheldon S. Miller: Section of Epithelial and Retinal Physiology and Disease, National Eye Institute, National Institutes of Health
Shahin Rafii: Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
Enrique Rodriguez-Boulan: Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine

DOI: https://doi.org/10.1038/ncomms15374
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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