Epidemiological characteristics and transmissibility of HPV infection: A long-term retrospective study in Hokkien Golden Triangle, China, 2013–2021
Jingwen Xu,
Guzainuer Abudurusuli,
Jia Rui,
Zhuoyang Li,
Zeyu Zhao,
Yilan Xia,
Xiaohao Guo,
Buasiyamu Abudunaibi,
Benhua Zhao,
Qiwei Guo,
Jing-An Cui,
Yulin Zhou,
Tianmu Chen
Affiliations
Jingwen Xu
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University; Health Emergency Office, Hefei Center for Disease Control and Prevention, Hefei City, Anhui Province, People’s Republic of China
Guzainuer Abudurusuli
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Jia Rui
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Zhuoyang Li
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Zeyu Zhao
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Yilan Xia
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Xiaohao Guo
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Buasiyamu Abudunaibi
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Benhua Zhao
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Qiwei Guo
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University
Jing-An Cui
Department of Mathematics, School of Science, Beijing University of Civil Engineering and Architecture, Beijing 102616, People’s Republic of China
Yulin Zhou
United Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine & School of Public Health, Xiamen University, Xiamen, Fujian 361102, People’s Republic of China; Correspondence to: United Diagnostic and Research Center for Clinical Genetics, Women and Children’ Hospital, School of Medicine & School of Public Health, Xiamen University, Xiamen, Fujian 361102, People’s Republic of China.
Tianmu Chen
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University; Correspondence to: State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen City 361102, Fujian Province, People’s Republic of China.
Objective: Multiple human papillomavirus (HPV)-associated diseases have put a significant disease burden on the world. Therefore, we conducted a study to explore the epidemiological characteristics of HPV and the transmissibility of its genotypes. Methods: HPV testing data was collected from Hospital. A transmission dynamics model of HPV was constructed to simulate and compare the transmissibility of different HPV genotypes, which was quantitatively described by the basic reproduction number (R0). Results: The collected HPV subjects were mainly from Xiamen City, Zhangzhou City and Quanzhou City, together, they are known as the Hokkien golden triangle. There were variations in the distribution of HPV infections by age groups. Among all HPV genotypes, 13 of them had R0 > 1, with 10 of them being high-risk types. The top five were HPV56, 18, 58, 52 and 53, among which, HPV56, 18, 58 and 42 were of high risk, whereas HPV53 was not, and the R0 values for the five were 3.35 (CI: 0.00–9.99), 3.20 (CI: 0.00–6.46), 3.19 (CI: 1.27–6.94), 3.19 (CI: 1.01–8.42) and 2.99 (CI: 0.00–9.39), respectively. In addition, HPV52 had R0 > 1 for about 51 months, which had the longest duration. Conclusion: Most high-risk HPV types in the Hokkien golden triangle could transmit among the population. Therefore, there is a need of further optimization for developing HPV vaccines and better detection methods in the region.
