Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review
Yunhua Cheng,
Liling Zhu,
Shuangxiong Xie,
Binyuan Lu,
Xiaoyu Du,
Guanjiang Ding,
Yan Wang,
Linchong Ma,
Qingxin Li
Affiliations
Yunhua Cheng
The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
Liling Zhu
Department of Anesthesiology, Hunan Children’s Hospital, Changsha, Hunan Province, China
Shuangxiong Xie
The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
Binyuan Lu
The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
Xiaoyu Du
Medical College of Northwest Minzu University, Northwest Minzu University, Lanzhou, Gansu Province, China
Guanjiang Ding
The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
Yan Wang
The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
Linchong Ma
Department of Thoracic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu Province, China
Qingxin Li
Department of Thoracic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu Province, China
Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI. Ferroptosis and mitophagy are both closely related to reactive oxygen species (ROS). Mitophagy can regulate ferroptosis, but the specific relationship between ferroptosis and mitophagy is still unclear. This study summarizes previous research findings on ferroptosis and mitophagy, revealing their involvement in ALI. Examining the functions of mTOR and NLPR3 helps clarify the connection between ferroptosis and mitophagy in ALI, with the goal of establishing a theoretical foundation for potential therapeutic approaches in the future management of ALI.
