Frontiers in Medicine (Feb 2022)

Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects

  • Riccardo Vinciguerra,
  • Robert Herber,
  • Yan Wang,
  • Yan Wang,
  • Fengju Zhang,
  • Xingtao Zhou,
  • Ji Bai,
  • Keming Yu,
  • Shihao Chen,
  • Xuejun Fang,
  • Frederik Raiskup,
  • Paolo Vinciguerra,
  • Paolo Vinciguerra

DOI
https://doi.org/10.3389/fmed.2022.834663
Journal volume & issue
Vol. 9

Abstract

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PurposeThe aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs).MethodsTwo thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm. The DCRs assessed were Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R), deformation amplitude ratio (DAratio), stiffness parameter at applanation 1 (SPA1), ARTh (Ambrósio's Relational Thickness to the horizontal profile), and the novel Stress Strain Index (SSI).ResultsAfter age-, CCT-, and IOP- matching, 503 Chinese were assigned to 452 Caucasians participants. Statistical analysis showed a statistical significant difference between Chinese and Caucasian Healthy subjects in the values of SPA1 (p = 0.008), Arth (p = 0.008), and SSI (p < 0.001). Conversely, DA, A1v, DAratio, and 1/R were not significantly different between the two ethnical groups (p > 0.05).ConclusionWe found significant differences in the values of the DCRs provided by the Corvis ST between Chinese and Caucasian healthy subjects.

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