Nature Communications (Jan 2018)
LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription
- Cui-Yun Liu,
- Yu-Hui Zhang,
- Rui-Bei Li,
- Lu-Yu Zhou,
- Tao An,
- Rong-Cheng Zhang,
- Mei Zhai,
- Yan Huang,
- Kao-Wen Yan,
- Yan-Han Dong,
- Murugavel Ponnusamy,
- Chan Shan,
- Sheng Xu,
- Qi Wang,
- Yan-Hui Zhang,
- Jian Zhang,
- Kun Wang
Affiliations
- Cui-Yun Liu
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Yu-Hui Zhang
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Rui-Bei Li
- School of Professional Studies, Northwestern University
- Lu-Yu Zhou
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Tao An
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Rong-Cheng Zhang
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Mei Zhai
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Yan Huang
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Kao-Wen Yan
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Yan-Han Dong
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Murugavel Ponnusamy
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Chan Shan
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Sheng Xu
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Qi Wang
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Yan-Hui Zhang
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- Jian Zhang
- State Key Laboratory of Cardiovascular Disease, Heart Failure center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
- Kun Wang
- Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
- DOI
- https://doi.org/10.1038/s41467-017-02280-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Little is known about the role of long lncRNAs in autophagy. The authors identify lncCAIF, and show that it suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53 -mediated transcription of myocardin.
