Nature Communications (Mar 2023)
Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies
- Qingyu Xu,
- Alexander Streuer,
- Johann-Christoph Jann,
- Eva Altrock,
- Nanni Schmitt,
- Johanna Flach,
- Carla Sens-Albert,
- Felicitas Rapp,
- Julia Wolf,
- Verena Nowak,
- Nadine Weimer,
- Julia Obländer,
- Iris Palme,
- Mariia Kuzina,
- Ahmed Jawhar,
- Ali Darwich,
- Cleo-Aron Weis,
- Alexander Marx,
- Patrick Wuchter,
- Victor Costina,
- Evelyn Jäger,
- Elena Sperk,
- Michael Neumaier,
- Alice Fabarius,
- Georgia Metzgeroth,
- Florian Nolte,
- Laurenz Steiner,
- Pavel A. Levkin,
- Mohamad Jawhar,
- Wolf-Karsten Hofmann,
- Vladimir Riabov,
- Daniel Nowak
Affiliations
- Qingyu Xu
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Alexander Streuer
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Johann-Christoph Jann
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Eva Altrock
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Nanni Schmitt
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Johanna Flach
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Carla Sens-Albert
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Felicitas Rapp
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Julia Wolf
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Verena Nowak
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Nadine Weimer
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Julia Obländer
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Iris Palme
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Mariia Kuzina
- Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology
- Ahmed Jawhar
- Department of Orthopedic Surgery, Medical Faculty Mannheim, Heidelberg University
- Ali Darwich
- Department of Orthopedic Surgery, Medical Faculty Mannheim, Heidelberg University
- Cleo-Aron Weis
- Institute of Pathology, Medical Faculty Mannheim, Heidelberg University
- Alexander Marx
- Institute of Pathology, Medical Faculty Mannheim, Heidelberg University
- Patrick Wuchter
- Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service Baden-Württemberg-Hessen, Medical Faculty Mannheim, Heidelberg University
- Victor Costina
- Institute of Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University
- Evelyn Jäger
- Institute of Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University
- Elena Sperk
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Michael Neumaier
- Institute of Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University
- Alice Fabarius
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Georgia Metzgeroth
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Florian Nolte
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Laurenz Steiner
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Pavel A. Levkin
- Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology
- Mohamad Jawhar
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Wolf-Karsten Hofmann
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Vladimir Riabov
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Daniel Nowak
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- DOI
- https://doi.org/10.1038/s41467-023-37175-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Hypomethylating agents, such as 5-Azacytidine (5-AZA), are standard of care for patients with myelodysplastic and myeloid malignancies, however response rates are limited and risk of relapses high. Here the authors show that inhibition of lysyl oxidases synergizes with 5-AZA to improve erythropoiesis and reduce disease burden in myelodysplastic neoplasms models.
