Nature Communications (May 2018)
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
- Quy H. Nguyen,
- Nicholas Pervolarakis,
- Kerrigan Blake,
- Dennis Ma,
- Ryan Tevia Davis,
- Nathan James,
- Anh T. Phung,
- Elizabeth Willey,
- Raj Kumar,
- Eric Jabart,
- Ian Driver,
- Jason Rock,
- Andrei Goga,
- Seema A. Khan,
- Devon A. Lawson,
- Zena Werb,
- Kai Kessenbrock
Affiliations
- Quy H. Nguyen
- Department of Biological Chemistry, University of California, Irvine
- Nicholas Pervolarakis
- Center for Complex Biological Systems, University of California, Irvine
- Kerrigan Blake
- Center for Complex Biological Systems, University of California, Irvine
- Dennis Ma
- Department of Biological Chemistry, University of California, Irvine
- Ryan Tevia Davis
- Department of Physiology and Biophysics, University of California, Irvine
- Nathan James
- Department of Biological Chemistry, University of California, Irvine
- Anh T. Phung
- Department of Physiology and Biophysics, University of California, Irvine
- Elizabeth Willey
- Department of Anatomy and Biomedical Sciences Program, University of California
- Raj Kumar
- Department of Anatomy and Biomedical Sciences Program, University of California
- Eric Jabart
- ProteinSimple, 3001 Orchard Parkway
- Ian Driver
- Department of Anatomy and Biomedical Sciences Program, University of California
- Jason Rock
- Department of Anatomy and Biomedical Sciences Program, University of California
- Andrei Goga
- Department of Cell and Tissue Biology, University of California
- Seema A. Khan
- Department of Surgery, Feinberg School of Medicine, Northwestern University
- Devon A. Lawson
- Department of Physiology and Biophysics, University of California, Irvine
- Zena Werb
- Department of Anatomy and Biomedical Sciences Program, University of California
- Kai Kessenbrock
- Department of Biological Chemistry, University of California, Irvine
- DOI
- https://doi.org/10.1038/s41467-018-04334-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells.
