Nature Communications (Nov 2017)
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
- Manisha Singh,
- Christina Vianden,
- Mark J. Cantwell,
- Zhimin Dai,
- Zhilan Xiao,
- Meenu Sharma,
- Hiep Khong,
- Ashvin R. Jaiswal,
- Faisal Faak,
- Yared Hailemichael,
- L. M. E. Janssen,
- Uddalak Bharadwaj,
- Michael A. Curran,
- Adi Diab,
- Roland L. Bassett,
- David J. Tweardy,
- Patrick Hwu,
- Willem W. Overwijk
Affiliations
- Manisha Singh
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Christina Vianden
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Mark J. Cantwell
- Memgen
- Zhimin Dai
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Zhilan Xiao
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Meenu Sharma
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Hiep Khong
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ashvin R. Jaiswal
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Faisal Faak
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yared Hailemichael
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- L. M. E. Janssen
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Uddalak Bharadwaj
- Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center
- Michael A. Curran
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Adi Diab
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Roland L. Bassett
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- David J. Tweardy
- Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Willem W. Overwijk
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-01572-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of mice.
