Neuroblasts migration under control of reactive astrocyte-derived BDNF: a promising therapy in late neurogenesis after traumatic brain injury

Abstract

Highlights 1. Neuroblasts migrated along the activated astrocytic tunnel, directed by BDNF gradient between SVZ and injured cortex after TBI. CCL2 might be a key regulator in the above endogenous neuroblasts migration. 2. Exogenous CCL2 promoted neuroblasts migration and reactive astrocytes-derived BDNF expression not only in normal mice but also in mice on day 28 after CCI. 3. Notably, these neuroblasts also possessed the potential to differentiate into mature neurons.

Keywords

• Traumatic brain injury
• Neuroblast
• Neuronal migration
• Brain-derived neurotrophic factor
• CC chemokine ligand 2
• Monocyte chemoattractant protein-1