p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Yuan Ge; Meng Tian; Lidong Liu; Tak Pan Wong; Bo Gong; Dongchuan Wu; Taesup Cho; Shujun Lin; Jürgen Kast; Jie Lu; Yu Tian Wang

doi:10.1038/s41467-019-12096-7

Nature Communications (Sep 2019)

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Yuan Ge,
Meng Tian,
Lidong Liu,
Tak Pan Wong,
Bo Gong,
Dongchuan Wu,
Taesup Cho,
Shujun Lin,
Jürgen Kast,
Jie Lu,
Yu Tian Wang

Affiliations

Yuan Ge: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Meng Tian: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Lidong Liu: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Tak Pan Wong: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Bo Gong: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Dongchuan Wu: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Taesup Cho: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Shujun Lin: Biomedical Research Centre, University of British Columbia
Jürgen Kast: Biomedical Research Centre, University of British Columbia
Jie Lu: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia
Yu Tian Wang: Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia

DOI: https://doi.org/10.1038/s41467-019-12096-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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