breast cancer, Syzygium malaccense, in silico study, virtual screening

Abstract

Oxidative substances that contain in cigarettes could cause oxidative stress and change the lipid profiles in High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL). However, oxidative stress could be inhibited by antioxidants from the extract of sweet orange peel. The effect of Citrus sinensis peel extract on HDL and LDL levels is investigated in this study. Wistar rats were employed as subjects in this study. The research subjects were divided into five groups, namely, normal control, given cigarette smoke without Citrus sinensis, and given Citrus sinensis peel extract. The results showed that the administration of Citrus sinensis peel extract could inhibit HDL reduction and increase LDL levels. The highest score of HDL levels is shown in the negative control group (37.5 mg/dL). On the other hand, the lowest shows in the normal control group (2.66 mg/dL) with a significant p < .001. The lowest post-test HDL levels were found in the negative control group. The highest post-test HDL levels were in group V. The highest difference in LDL levels was in the negative control group (53.57 mg/dL) and the lowest in the normal control group (3.26 mg/dL). The highest post-test LDL levels were found in group V. The lowest post-test LDL levels were in group V.

Keywords

• cigarette smoke
• citrus sinensis
• hdl
• ldl