Mycophenolate-induced eosinophilic colitis: A case report

Abstract

Mycophenolate mofetil is a medication used for the prevention of allograft rejection in organ transplant patients. Eosinophilic colitis due to mycophenolate is a recognized condition in patients with a history of renal transplantation and persistent diarrhea, requiring a biopsy to achieve an appropriate diagnosis and treatment. The case of an 11-year-old boy with diarrhea is presented; colon biopsy showed edema and eosinophilic inflammatory in-filtrate in the lamina propria with microabscess formation, with epithelial and crypt damage. Because of the absence of another cause of the clinical case, mycophenolate was withdrawn from the treatment scheme, with re-solution of the symptoms. The Naranjo adverse drug reaction probability scale was definitive with a score of 10. The report contributes to the literature with the characterization of the histopathological findings in mycophenolate-induced colonic injury.

Keywords

• colitis
• mycophenolic acid
• diarrhea