The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue

Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Shogo Sato; Yoshinaga Ishibashi; Motoko Takahashi; Osamu Kobayashi; Shuji Oh-ishi; Junichi Nagasawa; Kazuto Takahashi; Hitoshi Ishida; Tetsuya Izawa; Hideki Ohno

doi:10.1155/2013/801743

International Journal of Endocrinology (Jan 2013)

The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue

Takuya Sakurai,
Junetsu Ogasawara,
Takako Kizaki,
Shogo Sato,
Yoshinaga Ishibashi,
Motoko Takahashi,
Osamu Kobayashi,
Shuji Oh-ishi,
Junichi Nagasawa,
Kazuto Takahashi,
Hitoshi Ishida,
Tetsuya Izawa,
Hideki Ohno

Affiliations

Takuya Sakurai: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Junetsu Ogasawara: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Takako Kizaki: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Shogo Sato: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Yoshinaga Ishibashi: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Motoko Takahashi: Department of Biochemistry, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan
Osamu Kobayashi: Department of Nursing, Kyorin University, Faculty of Health Science, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Shuji Oh-ishi: Department of Respiratory Medicine, Hachioji Medical Center, Tokyo Medical University, 1163 Tatemachi, Hachioji, Tokyo 193-0998, Japan
Junichi Nagasawa: Department of Applied Physics and Chemistry, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan
Kazuto Takahashi: Third Department of Internal Medicine, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Hitoshi Ishida: Third Department of Internal Medicine, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Tetsuya Izawa: Department of Sports Biochemistry, Faculty of Health and Sport Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan
Hideki Ohno: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan

DOI: https://doi.org/10.1155/2013/801743
Journal volume & issue: Vol. 2013

Abstract

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Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.

Published in International Journal of Endocrinology

ISSN: 1687-8337 (Print); 1687-8345 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://onlinelibrary.wiley.com/journal/1573

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