999 The PTPN2/N1 small molecule inhibitor ABBV-CLS-484 promotes NK cell activity driving primary tumor regression and preventing metastasis

• Chirag Patel,
• Meng Sun,
• Yue Liu,
• Jonathan Powell,
• Kyle Halliwill,
• Jennifer M Frost,
• Robert T Manguso,
• Kathleen B Yates,
• Hakimeh Ebrahimi-Nik,
• Christina K Baumgartner,
• Keith M Hamel,
• Kira Olander,
• Kathleen A McGuire,
• Audrey J Muscato,
• Kelly Klinge,
• Joseph Klahn,
• Jacqueline Aguado,
• Payal Tiwari,
• Kayla J Colvin,
• Marcia N Paddock,
• Philip R Kym,
• Omar Avila-Monge,
• Alexander Schutte

Affiliations

Chirag Patel

Calico Life Sciences, South San Francisco, CA, USA

Meng Sun

7Calico Life Sciences, South San Francisco, CA, USA

Yue Liu

7Calico Life Sciences, South San Francisco, CA, USA

Jonathan Powell

Calico Life Sciences, South San Francisco, CA, USA

Kyle Halliwill

8AbbVie, San Bruno, CA, USA

Jennifer M Frost

4AbbVie Inc., North Chicago, IL, USA

Robert T Manguso

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Kathleen B Yates

3Broad Institute of MIT and Harvard, Cambridge, MA, USA

Hakimeh Ebrahimi-Nik

1Somerville, MA, USA

Christina K Baumgartner

4AbbVie Inc., North Chicago, IL, USA

Keith M Hamel

4AbbVie Inc., North Chicago, IL, USA

Kira Olander

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kathleen A McGuire

4AbbVie Inc., North Chicago, IL, USA

Audrey J Muscato

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kelly Klinge

4AbbVie Inc., North Chicago, IL, USA

Joseph Klahn

11AbbVie, Elk Grove Village, IL, USA

Jacqueline Aguado

4AbbVie Inc., North Chicago, IL, USA

Payal Tiwari

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kayla J Colvin

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Marcia N Paddock

7Calico Life Sciences, South San Francisco, CA, USA

Philip R Kym

4AbbVie Inc., North Chicago, IL, USA

Omar Avila-Monge

3Broad Institute of MIT and Harvard, Cambridge, MA, USA

Alexander Schutte

2AbbVie Inc., North Chicago, IL, USA