Nature Communications (Mar 2020)

An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y

  • Laura Broglia,
  • Anne-Laure Lécrivain,
  • Thibaud T. Renault,
  • Karin Hahnke,
  • Rina Ahmed-Begrich,
  • Anaïs Le Rhun,
  • Emmanuelle Charpentier

DOI
https://doi.org/10.1038/s41467-020-15387-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease PNPase and YhaM.