The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury

Yuan Zhang; Yuan Zhang; Yuan Zhang; Yiyuan Li; Xiaolong Fu; Pengjun Wang; Qin Wang; Wei Meng; Tian Wang; Jianming Yang; Renjie Chai; Renjie Chai; Renjie Chai

doi:10.3389/fcell.2021.631904

Frontiers in Cell and Developmental Biology (Aug 2021)

The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury

Yuan Zhang,
Yuan Zhang,
Yuan Zhang,
Yiyuan Li,
Xiaolong Fu,
Pengjun Wang,
Qin Wang,
Wei Meng,
Tian Wang,
Jianming Yang,
Renjie Chai,
Renjie Chai,
Renjie Chai

Affiliations

Yuan Zhang: MOE Key Laboratory for Developmental Genes and Human Disease, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Yuan Zhang: Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China
Yuan Zhang: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Yiyuan Li: MOE Key Laboratory for Developmental Genes and Human Disease, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Xiaolong Fu: MOE Key Laboratory for Developmental Genes and Human Disease, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Pengjun Wang: Department of Otorhinolaryngology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai, China
Qin Wang: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China
Wei Meng: Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China
Tian Wang: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China
Jianming Yang: Department of Otorhinolaryngology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Renjie Chai: MOE Key Laboratory for Developmental Genes and Human Disease, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Renjie Chai: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Renjie Chai: Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

DOI: https://doi.org/10.3389/fcell.2021.631904
Journal volume & issue: Vol. 9

Abstract

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Macrophages are the main intrinsic immune cells in the cochlea; they can be activated and play a complicated role after cochlear injury. Many studies have shown that the number of macrophages and their morphological characteristics within the major cochlear partitions undergo significant changes under various pathological conditions including acoustic trauma, ototoxic drug treatment, age-related cochlear degeneration, selective hair cell (HC) and spiral ganglion neuron (SGN) elimination, and surgery. However, the exact role of these macrophages after cochlear injury is still unclear. Regulating the migration and activity of macrophages may be a therapeutic approach to reduce the risk or magnitude of trauma-induced hearing loss, and this review highlights the role of macrophages on the peripheral auditory structures of the cochlea and elucidate the mechanisms of macrophage injury and the strategies to reduce the injury by regulating macrophage.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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