Nature Communications (Jan 2018)

Injury-activated glial cells promote wound healing of the adult skin in mice

  • Vadims Parfejevs,
  • Julien Debbache,
  • Olga Shakhova,
  • Simon M. Schaefer,
  • Mareen Glausch,
  • Michael Wegner,
  • Ueli Suter,
  • Una Riekstina,
  • Sabine Werner,
  • Lukas Sommer

DOI
https://doi.org/10.1038/s41467-017-01488-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.