Nature Communications (Oct 2021)
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region
- Ivy Aneas,
- Donna C. Decker,
- Chanie L. Howard,
- Débora R. Sobreira,
- Noboru J. Sakabe,
- Kelly M. Blaine,
- Michelle M. Stein,
- Cara L. Hrusch,
- Lindsey E. Montefiori,
- Juan Tena,
- Kevin M. Magnaye,
- Selene M. Clay,
- James E. Gern,
- Daniel J. Jackson,
- Matthew C. Altman,
- Edward T. Naureckas,
- Douglas K. Hogarth,
- Steven R. White,
- Jose Luis Gomez-Skarmeta,
- Nathan Schoetler,
- Carole Ober,
- Anne I. Sperling,
- Marcelo A. Nóbrega
Affiliations
- Ivy Aneas
- Department of Human Genetics, University of Chicago
- Donna C. Decker
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Chanie L. Howard
- Committee on Immunology, University of Chicago
- Débora R. Sobreira
- Department of Human Genetics, University of Chicago
- Noboru J. Sakabe
- Department of Human Genetics, University of Chicago
- Kelly M. Blaine
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Michelle M. Stein
- Department of Human Genetics, University of Chicago
- Cara L. Hrusch
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Lindsey E. Montefiori
- Department of Human Genetics, University of Chicago
- Juan Tena
- Centro Andaluz de Biología del Desarrollo (CSIC/UPO/JA), Universidad Pablo de Olavide
- Kevin M. Magnaye
- Department of Human Genetics, University of Chicago
- Selene M. Clay
- Department of Human Genetics, University of Chicago
- James E. Gern
- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health
- Daniel J. Jackson
- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health
- Matthew C. Altman
- Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington
- Edward T. Naureckas
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Douglas K. Hogarth
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Steven R. White
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Jose Luis Gomez-Skarmeta
- Centro Andaluz de Biología del Desarrollo (CSIC/UPO/JA), Universidad Pablo de Olavide
- Nathan Schoetler
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Carole Ober
- Department of Human Genetics, University of Chicago
- Anne I. Sperling
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago
- Marcelo A. Nóbrega
- Department of Human Genetics, University of Chicago
- DOI
- https://doi.org/10.1038/s41467-021-26347-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Susceptibility to asthma and severity of symptoms are regulated by a number of different genomic regions. Here the authors characterise a 5kb regulatory region and demonstrate genetic and topological regulation of IL33 and association with disease in different human cohorts.
