Frontiers in Neuroinformatics (Jan 2025)
The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint
- Hakim Baazaoui,
- Stefan T. Engelter,
- Stefan T. Engelter,
- Stefan T. Engelter,
- Henrik Gensicke,
- Henrik Gensicke,
- Henrik Gensicke,
- Lukas S. Enz,
- Lukas S. Enz,
- Marios Psychogios,
- Marios Psychogios,
- Matthias Mutke,
- Matthias Mutke,
- Patrik Michel,
- Davide Strambo,
- Alexander Salerno,
- Henk A. Marquering,
- Paul J. Nederkoorn,
- Nabila Wali,
- Stephanie Tanadini-Lang,
- Björn Menze,
- Ezequiel de la Rosa,
- Kaiyuan Yang,
- Gian Marco De Marchis,
- Gian Marco De Marchis,
- Tolga D. Dittrich,
- Tolga D. Dittrich,
- Francesco Valletta,
- Francesco Valletta,
- Manon Germann,
- Carlo W. Cereda,
- João Pedro Marto,
- Lisa Herzog,
- Patrick Hirschi,
- Zsolt Kulcsar,
- Susanne Wegener,
- Susanne Wegener
Affiliations
- Hakim Baazaoui
- Department of Neurology, University Hospital Zurich, Zurich, Switzerland
- Stefan T. Engelter
- Neurorehabilitation and Neurology, University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland
- Stefan T. Engelter
- Department of Neurology and Stroke Center, University of Basel and University Hospital Basel, Basel, Switzerland
- Stefan T. Engelter
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Henrik Gensicke
- Neurorehabilitation and Neurology, University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland
- Henrik Gensicke
- Department of Neurology and Stroke Center, University of Basel and University Hospital Basel, Basel, Switzerland
- Henrik Gensicke
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Lukas S. Enz
- Department of Neurology and Stroke Center, University of Basel and University Hospital Basel, Basel, Switzerland
- Lukas S. Enz
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Marios Psychogios
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Marios Psychogios
- Department of Neuroradiology, University Hospital Basel, Basel, Switzerland
- Matthias Mutke
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Matthias Mutke
- Department of Neuroradiology, University Hospital Basel, Basel, Switzerland
- Patrik Michel
- Stroke Center, Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
- Davide Strambo
- Stroke Center, Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
- Alexander Salerno
- Stroke Center, Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
- Henk A. Marquering
- Radiology and Nuclear Medicine/Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, Netherlands
- Paul J. Nederkoorn
- Department of Neurology, Amsterdam University Medical Centers, Amsterdam, Netherlands
- Nabila Wali
- Department of Neurology, Amsterdam University Medical Centers, Amsterdam, Netherlands
- Stephanie Tanadini-Lang
- Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
- Björn Menze
- 0Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
- Ezequiel de la Rosa
- 0Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
- Kaiyuan Yang
- 0Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
- Gian Marco De Marchis
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Gian Marco De Marchis
- 1Department of Neurology and Stroke Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
- Tolga D. Dittrich
- Department of Clinical Research, University of Basel, Basel, Switzerland
- Tolga D. Dittrich
- 1Department of Neurology and Stroke Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
- Francesco Valletta
- 1Department of Neurology and Stroke Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
- Francesco Valletta
- 2DAI di Neuroscienze, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
- Manon Germann
- 3Department of Radiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
- Carlo W. Cereda
- 4Stroke Center EOC, Neurocenter of Southern Switzerland, Lugano, Switzerland
- João Pedro Marto
- 5Department of Neurology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
- Lisa Herzog
- Department of Neurology, University Hospital Zurich, Zurich, Switzerland
- Patrick Hirschi
- 6Clinical Data Platform for Research, University Hospital Zurich, Zurich, Switzerland
- Zsolt Kulcsar
- 7Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland
- Susanne Wegener
- Department of Neurology, University Hospital Zurich, Zurich, Switzerland
- Susanne Wegener
- 8Neuroscience Center Zurich, University of Zurich and ETH, Zurich, Switzerland
- DOI
- https://doi.org/10.3389/fninf.2024.1508161
- Journal volume & issue
-
Vol. 18
Abstract
PurposeThe Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven stroke centres in Europe. MAGIC consolidates clinical and radiological data from acute ischemic stroke (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, a combination of both, or conservative management.ParticipantsAll centres ensure accuracy and completeness of the data. Only patients who did not refuse use of their routine data collected during or after their hospital stay are included in the repository. Approvals or waivers are obtained from the responsible ethics committees before data exchange. A formal data transfer agreement (DTA) is signed by all contributing centres. The centres then share their data, and files are stored centrally on a safe server at the University Hospital Zurich. There, patient identifiers are removed and images are algorithmically de-faced. De-identified structured clinical data are connected to the imaging data by a new identifier. Data are made available to participating centres which have entered into a DTA for stroke research projects.Repository setupInitially, MAGIC is set to comprise initial and first follow-up imaging of 2,500 AIS patients. Clinical data consist of a comprehensive set of patient characteristics and routine prehospital metrics, treatment and laboratory variables.OutlookOur repository will support research by leveraging the entire range of routinely collected imaging and clinical data. This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. We aim to reach approximately 10,000 cases by 2026.
Keywords
