Diabetes, Metabolic Syndrome and Obesity (Apr 2020)
The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
Abstract
Jia Feng,1,2 Shiyin Lu,1,2 Biqian Ou,1,2 Qian Liu,1,2 Jiaxin Dai,1,2 Chunyan Ji,1,2 Haiqing Zhou,1,2 Hongke Huang,1,2 Yi Ma1,2 1Institute of Biomedicine, Department of Cellular Biology, Jinan University, Guangzhou, People’s Republic of China; 2National Engineering Research Center of Genetic Medicine, Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Yi MaInstitute of Biomedicine, Department of Cellular Biology, Jinan University, 601 Huangpu Ave West, Guangzhou, Guangdong 510632, People’s Republic of ChinaTel/Fax +86 20 8522 1983Email [email protected]: Obesity is not only closely related to insulin resistance but is one of the main factors leading to the formation of Type 2 Diabetes (T2D) too. The c-Jun N-terminal kinase (JNK) family is a member of the mitogen-activated protein kinase (MAPK) superfamily. JNK is also one of the most investigated signal transducers in obesity and insulin resistance. JNK-centric JNK signaling pathway can be activated by growth factors, cytokines, stress responses, and other factors. Many researches have identified that the activated phosphorylation JNK negatively regulates insulin signaling pathway in insulin resistance which can be simultaneously regulated by multiple signaling pathways related to the JNK signaling pathway. In this review, we provide an overview of the composition of the JNK signaling pathway, its regulation of insulin signaling pathway, and the relationship between the JNK signaling pathway and other pathways in insulin resistance.Keywords: JNK signaling pathway, obesity, insulin resistance, type 2 diabetes
