Neuropsychiatric Disease and Treatment (Mar 2024)
Severe Refractory Obsessive Compulsive Disorder and Depression: Should We Consider Stereotactic Neurosurgery?
Abstract
Ludvic Zrinzo Unit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UKCorrespondence: Ludvic Zrinzo, Functional Neurosurgery Unit, Department of Clinical & Motor Neurosciences, UCL Institute of Neurology, Second Floor, 33 Queen Square, London, WC1N 3BG, U.K, Email [email protected]: Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as “standard of care”, benefiting hundreds of thousands of patients. As with movement disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder and depression, can be framed as disorders of neural networks. Over the past two decades, evidence has accumulated that stereotactic neurosurgery can help some patients with mental disorders. Nevertheless, despite the availability of class I evidence for some interventions, there is a huge mismatch between the prevalence of severe refractory mental disorders and the number of referrals made to specialised functional neurosurgery services. This paper examines the historical trajectory of neurosurgery for movement and mental disorders. A review of neurosurgical techniques, including stereotactic radiofrequency ablation, gamma knife, deep brain stimulation, and magnetic resonance imaging guided focused ultrasound, explains the high degree of safety afforded by technological advances in the field. Evidence from clinical trials supporting functional neurosurgery for mental disorders, including obsessive compulsive disorder and depression, is presented. An improved understanding of modern functional neurosurgery should foster collaboration between psychiatry and neurosurgery, providing hope to patients whose symptoms are refractory to all other treatments.Keywords: stereotactic neurosurgery, deep brain stimulation, obsessive compulsive disorder, major depression, stereotactic ablation, focused ultrasound
