Propofol Sedation Dose for MRI Examination in Autistic Children Compared with normal Children.

Abstract

Abstract Introduction; MRI examination is a standard procedure requested by physicians of neurologic sciences, for the patient with neurocognitive disorders. Propofol sedation was performed for this examination, and we had the suspicion that children with autism spectrum syndrome (AUT) required higher propofol dose than normal children. Materials and methods. During a six years period, the first group of 30 autistic patients aged 3 to 10 years, received propofol infusion for brain MR, the control group of 30 normal patients with the same age, and the same mid-time of examination MR was also performed. Results. 17 children of AUT group received 3±1 additional doses of propofol, 12 of them had to repeat MR sequences (adequate anesthesia) and the total dose of propofol 4,5 vs 3,6 compare to non-autistic children. Even and the recovery time is a little bit faster compared to the second group. Conclusion: Autistic patients require more propofol dose to achieve a desirable level of anesthesia. All anesthesiologists should be aware in such patients with mental disorders when using propofol anesthesia.

Keywords

• autism
• propofol dose
• MR examination