Potential of Ilhéus virus to emerge

Kenneth S. Plante; Jessica A. Plante; Sasha R. Azar; Divya P. Shinde; Dionna Scharton; Alice F. Versiani; Natalia Ingrid Oliveira da Silva; Taylor Strange; Lívia Sacchetto; Eric B. Fokam; Shannan L. Rossi; Scott C. Weaver; Rafael E. Marques; Mauricio L. Nogueira; Nikos Vasilakis

Heliyon (Mar 2024)

Potential of Ilhéus virus to emerge

Kenneth S. Plante,
Jessica A. Plante,
Sasha R. Azar,
Divya P. Shinde,
Dionna Scharton,
Alice F. Versiani,
Natalia Ingrid Oliveira da Silva,
Taylor Strange,
Lívia Sacchetto,
Eric B. Fokam,
Shannan L. Rossi,
Scott C. Weaver,
Rafael E. Marques,
Mauricio L. Nogueira,
Nikos Vasilakis

Affiliations

Kenneth S. Plante: World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Jessica A. Plante: World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Sasha R. Azar: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Center for Tissue Engineering, Department of Surgery, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA
Divya P. Shinde: World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Dionna Scharton: World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Alice F. Versiani: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Natalia Ingrid Oliveira da Silva: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Taylor Strange: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA
Lívia Sacchetto: Laboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, 15090-000, SP, Brazil
Eric B. Fokam: Laboratory for Biodiversity and Conservation Biology, Department of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea, Cameroon
Shannan L. Rossi: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, 77555, USA; Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA
Scott C. Weaver: World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, 77555, USA
Rafael E. Marques: Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, 13083-100, SP, Brazil
Mauricio L. Nogueira: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Laboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, 15090-000, SP, Brazil; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, 13083-100, SP, Brazil
Nikos Vasilakis: Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, 77555, USA; Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA; Corresponding author. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Journal volume & issue: Vol. 10, no. 6
p. e27934

Abstract

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Ilhéus virus (ILHV)(Flaviviridae:Orthoflavivirus) is an arthropod-borne virus (arbovirus) endemic to Central and South America and the Caribbean. First isolated in 1944, most of our knowledge derives from surveillance and seroprevalence studies. These efforts have detected ILHV in a broad range of mosquito and vertebrate species, including humans, but laboratory investigations of pathogenesis and vector competence have been lacking. Here, we develop an immune intact murine model with several ages and routes of administration. Our model closely recapitulates human neuroinvasive disease with ILHV strain- and mouse age-specific virulence, as well as a uniformly lethal Ifnar−/− A129 immunocompromised model. Replication kinetics in several vertebrate and invertebrate cell lines demonstrate that ILHV is capable of replicating to high titers in a wide variety of potential host and vector species. Lastly, vector competence studies provide strong evidence for efficient infection of and potential transmission by Aedes species mosquitoes, despite ILHV's phylogenetically clustering with Culex vectored flaviviruses, suggesting ILHV is poised for emergence in the neotropics.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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