Correlation between malondialdehyde and dyslipidemia in psoriatic patients

Abstract

Objectives This study was designed to investigate the correlation between serum lipid profile and lipid peroxidation as malondialdehyde (MDA) in psoriatic patients. Methods This case–control study was performed on 70 psoriatic patients and 30 healthy individuals as control, matched for age and sex. The blood samples were collected after 14 h fasting. The serum lipid profile was assayed using the standard kit and MDA was assayed using the ELISA kit. Results The certain parameters, including serum triglyceride, cholesterol, low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL), were significantly higher in the case group compared to the controls (P < 0.05), while high-density lipoproteincholesterol (HDL-C) remained within normal limit in the patients group compared to the control, while there was a significantly higher levels in MDA in case group as compared to that found in the controls (P < 0.05). Conclusion These results have revealed the higher plasma level of lipid profiles in psoriatic patients. This may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view, on screening the psoriatic patients, particularly those with severe psoriasis, is recommended.

Keywords

• psoriasis, lipid profile, malondialdehyde