Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

Ivan Jozic; Beatriz Abdo Abujamra; Michael H. Elliott; Tongyu C. Wikramanayake; Jelena Marjanovic; Rivka C. Stone; Cheyanne R. Head; Irena Pastar; Robert S. Kirsner; Fotios M. Andreopoulos; Juan P. Musi; Marjana Tomic-Canic

doi:10.1038/s42003-021-02298-5

Communications Biology (Jun 2021)

Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

Ivan Jozic,
Beatriz Abdo Abujamra,
Michael H. Elliott,
Tongyu C. Wikramanayake,
Jelena Marjanovic,
Rivka C. Stone,
Cheyanne R. Head,
Irena Pastar,
Robert S. Kirsner,
Fotios M. Andreopoulos,
Juan P. Musi,
Marjana Tomic-Canic

Affiliations

Ivan Jozic: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Beatriz Abdo Abujamra: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Michael H. Elliott: Departments of Ophthalmology, Physiology, and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center
Tongyu C. Wikramanayake: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Jelena Marjanovic: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Rivka C. Stone: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Cheyanne R. Head: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Irena Pastar: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Robert S. Kirsner: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Fotios M. Andreopoulos: Department of Biomedical Engineering, University of Miami
Juan P. Musi: Department of Biomedical Engineering, University of Miami
Marjana Tomic-Canic: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02298-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Jozic et al observe deregulated cytoskeleton components and elevated levels of cortisol and caveolin-1 in chronic wounds. They also show that inducible-keratinocyte specific Cav1 knockout or drug-induced cholesterol disruption in diabetic mice leads to accelerated wound closure suggesting a therapeutic approach for diabetic foot ulcers.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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