Phosphorylation disrupts long-distance electron transport in cytochrome c

Alexandre M. J. Gomila; Gonzalo Pérez-Mejías; Alba Nin-Hill; Alejandra Guerra-Castellano; Laura Casas-Ferrer; Sthefany Ortiz-Tescari; Antonio Díaz-Quintana; Josep Samitier; Carme Rovira; Miguel A. De la Rosa; Irene Díaz-Moreno; Pau Gorostiza; Marina I. Giannotti; Anna Lagunas

doi:10.1038/s41467-022-34809-1

Nature Communications (Nov 2022)

Phosphorylation disrupts long-distance electron transport in cytochrome c

Alexandre M. J. Gomila,
Gonzalo Pérez-Mejías,
Alba Nin-Hill,
Alejandra Guerra-Castellano,
Laura Casas-Ferrer,
Sthefany Ortiz-Tescari,
Antonio Díaz-Quintana,
Josep Samitier,
Carme Rovira,
Miguel A. De la Rosa,
Irene Díaz-Moreno,
Pau Gorostiza,
Marina I. Giannotti,
Anna Lagunas

Affiliations

Alexandre M. J. Gomila: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Gonzalo Pérez-Mejías: Institute for Chemical Research–cicCartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC)
Alba Nin-Hill: University of Barcelona, Department of Inorganic and Organic Chemistry, Institute of Theoretical Chemistry (IQTCUB)
Alejandra Guerra-Castellano: Institute for Chemical Research–cicCartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC)
Laura Casas-Ferrer: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Sthefany Ortiz-Tescari: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Antonio Díaz-Quintana: Institute for Chemical Research–cicCartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC)
Josep Samitier: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Carme Rovira: University of Barcelona, Department of Inorganic and Organic Chemistry, Institute of Theoretical Chemistry (IQTCUB)
Miguel A. De la Rosa: Institute for Chemical Research–cicCartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC)
Irene Díaz-Moreno: Institute for Chemical Research–cicCartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC)
Pau Gorostiza: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Marina I. Giannotti: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)
Anna Lagunas: Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST)

DOI: https://doi.org/10.1038/s41467-022-34809-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Electron transfer between mitochondrial cytochrome c and subunit of cytochrome bc 1 can proceed at long distance. Here the authors investigate further the mechanism and show phosphorylation regulation of the interactions between the protein partners in the electron transport chain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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