8-Oxo-7,8-dihydro-2′-deoxyguanosine values measured in brain DNA of rats upon investigating cortexin protective action

Abstract

The protective effect of cortexin was investigated with the use of acoustic stress hemorrhagic stroke model. A significant decrease of 8-oxo-2'-deoxyguanosine to 2'-deoxyguanosine ratio in the DNA molecule was shown using brain slices of cortexin treated Krushinsky-Molodkina rats.

Keywords

• cortexin
• 8-oxo-2'-deoxyguanosine
• oxidative stress
• reverse phase hplc
• amperometric detection
• hemorrhagic stroke
• acoustic stress