Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
Kai-Leng Tan,
King-Hwa Ling,
Chelsee A. Hewitt,
Pike-See Cheah,
Ken Simpson,
Lavinia Gordon,
Melanie A. Pritchard,
Gordon K. Smyth,
Tim Thomas,
Hamish S. Scott
Affiliations
Kai-Leng Tan
Neurobiology and Genetics Group, GRMRC-Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
King-Hwa Ling
Neurobiology and Genetics Group, GRMRC-Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Chelsee A. Hewitt
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Pike-See Cheah
Neurobiology and Genetics Group, GRMRC-Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Ken Simpson
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Lavinia Gordon
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Melanie A. Pritchard
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
Gordon K. Smyth
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Tim Thomas
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Hamish S. Scott
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2,3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database.
