Nature Communications (May 2020)

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

  • Maira Di Tano,
  • Franca Raucci,
  • Claudio Vernieri,
  • Irene Caffa,
  • Roberta Buono,
  • Maura Fanti,
  • Sebastian Brandhorst,
  • Giuseppe Curigliano,
  • Alessio Nencioni,
  • Filippo de Braud,
  • Valter D. Longo

DOI
https://doi.org/10.1038/s41467-020-16243-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Fasting diets are emerging as an approach to delay tumor progression and improve cancer therapies. Here, the authors show that the combination of fasting-mimicking diet with vitamin C decreases tumor development and increases chemotherapy efficacy in KRAS-mutant cancer.