The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Beatrice Formicola; Roberta Dal Magro; Carlos V. Montefusco-Pereira; Claus-Michael Lehr; Marcus Koch; Laura Russo; Gianvito Grasso; Marco A. Deriu; Andrea Danani; Sandrine Bourdoulous; Francesca Re

doi:10.1186/s12951-019-0546-3

Journal of Nanobiotechnology (Nov 2019)

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Beatrice Formicola,
Roberta Dal Magro,
Carlos V. Montefusco-Pereira,
Claus-Michael Lehr,
Marcus Koch,
Laura Russo,
Gianvito Grasso,
Marco A. Deriu,
Andrea Danani,
Sandrine Bourdoulous,
Francesca Re

Affiliations

Beatrice Formicola: School of Medicine and Surgery, University of Milano-Bicocca
Roberta Dal Magro: School of Medicine and Surgery, University of Milano-Bicocca
Carlos V. Montefusco-Pereira: Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University
Claus-Michael Lehr: Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University
Marcus Koch: Leibniz Institute for New Materials
Laura Russo: Bio Organic Chemistry Laboratory, Department of Biotechnology and Biosciences, University of Milano-Bicocca
Gianvito Grasso: Istituto Dalle Molle di Studi Sull’Intelligenza Artificiale (IDSIA), Scuola Universitaria Professionale Della Svizzera Italiana (SUPSI), Università Della Svizzera Italiana (USI)
Marco A. Deriu: Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino
Andrea Danani: Istituto Dalle Molle di Studi Sull’Intelligenza Artificiale (IDSIA), Scuola Universitaria Professionale Della Svizzera Italiana (SUPSI), Università Della Svizzera Italiana (USI)
Sandrine Bourdoulous: U1016, Institut Cochin, Inserm
Francesca Re: School of Medicine and Surgery, University of Milano-Bicocca

DOI: https://doi.org/10.1186/s12951-019-0546-3
Journal volume & issue: Vol. 17, no. 1
pp. 1 – 7

Abstract

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Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

Published in Journal of Nanobiotechnology

ISSN: 1477-3155 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Medicine: Medicine (General): Medical technology
Website: https://jnanobiotechnology.biomedcentral.com/

About the journal

Abstract

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