Localization of Generalized Spike and Wave Discharge and Valproate Response

Abstract

Investigators at Universities of Cincinnati, OH, and Birmingham, Alabama; and Montreal Neurological Institute, Canada, studied the EEG and functional magnetic resonance imaging (fMRI) in 89 patients with idiopathic generalized epilepsy (IGE), (25 with generalized spike and wave discharges (GSWD) identified in EEG), and compared patients with valproate (VPA)-refractory and VPA-responsive IGE.

Keywords

• idiopathic generalized epilepsy
• generalized spike and wave discharges
• blood oxygen-level dependent