Nature Communications (May 2019)
Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
- Mizuo Ando,
- Yuki Saito,
- Guorong Xu,
- Nam Q. Bui,
- Kate Medetgul-Ernar,
- Minya Pu,
- Kathleen Fisch,
- Shuling Ren,
- Akihiro Sakai,
- Takahito Fukusumi,
- Chao Liu,
- Sunny Haft,
- John Pang,
- Adam Mark,
- Daria A. Gaykalova,
- Theresa Guo,
- Alexander V. Favorov,
- Srinivasan Yegnasubramanian,
- Elana J. Fertig,
- Patrick Ha,
- Pablo Tamayo,
- Tatsuya Yamasoba,
- Trey Ideker,
- Karen Messer,
- Joseph A. Califano
Affiliations
- Mizuo Ando
- Moores Cancer Center, University of California San Diego
- Yuki Saito
- Moores Cancer Center, University of California San Diego
- Guorong Xu
- Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego
- Nam Q. Bui
- Department of Medicine, University of California San Diego
- Kate Medetgul-Ernar
- Moores Cancer Center, University of California San Diego
- Minya Pu
- Moores Cancer Center, University of California San Diego
- Kathleen Fisch
- Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego
- Shuling Ren
- Moores Cancer Center, University of California San Diego
- Akihiro Sakai
- Moores Cancer Center, University of California San Diego
- Takahito Fukusumi
- Moores Cancer Center, University of California San Diego
- Chao Liu
- Moores Cancer Center, University of California San Diego
- Sunny Haft
- Moores Cancer Center, University of California San Diego
- John Pang
- Moores Cancer Center, University of California San Diego
- Adam Mark
- Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego
- Daria A. Gaykalova
- Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine
- Theresa Guo
- Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine
- Alexander V. Favorov
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Srinivasan Yegnasubramanian
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Elana J. Fertig
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Patrick Ha
- Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, 2380 Sutter St
- Pablo Tamayo
- Moores Cancer Center, University of California San Diego
- Tatsuya Yamasoba
- Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, University of Tokyo
- Trey Ideker
- Department of Medicine, University of California San Diego
- Karen Messer
- Moores Cancer Center, University of California San Diego
- Joseph A. Califano
- Moores Cancer Center, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-019-09937-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.
