Physicochemical properties and in vitro activity of SrHPO4 modified magnesium oxychloride bone cement

Abstract

In response to the shortcomings of magnesium oxychloride cement (MOC), which has excellent with outstanding mechanical properties and favorable bioactivity but poor water resistance, strontium hydrogen phosphate (SrHPO _4 ) was used as a water resistance modifier for MOC in the paper, and the effects of SrHPO _4 on the strength, water resistance, in vitro degradation and bioactivity of MOC were investigated; the results showed that SrHPO _4 could enhance the water resistance of MOC, in which the initial strength of MOC containing 4.0 wt% SrHPO _4 was 92.3 ± 2.5 MPa, and the strength was still 8.2 ± 0.9 MPa after 84 d of immersion in SBF solution; the degradation experiments of the samples in SBF solution showed that the degradation of SrHPO _4 -MOC was controlled, and the low alkaline environment created by the degradation promoted the deposition of hydroxyapatite on the cement surface, it indicated that SrHPO _4 -MOC material had good degradation properties and bioactivity; cell experiments showed that compared with MOC, SrHPO _4 -MOC was noncytotoxic and could promote cell proliferation, which was expected to be a new material for bone repair.

Keywords

• magnesium oxychloride cement
• strontium hydrogen phosphate
• water resistance
• degradation performance
• biological activity