The Lancet Regional Health - Southeast Asia (Aug 2024)
Uniqueness of lung cancer in Southeast Asia
- Vanita Noronha,
- Atul Budukh,
- Pankaj Chaturvedi,
- Srikanth Anne,
- Anshu Punjabi,
- Maheema Bhaskar,
- Tarini P. Sahoo,
- Nandini Menon,
- Minit Shah,
- Ullas Batra,
- Shrinidhi Nathany,
- Rajiv Kumar,
- Omshree Shetty,
- Trupti Pai Ghodke,
- Abhishek Mahajan,
- Nivedita Chakrabarty,
- Supriya Hait,
- Satyendra C. Tripathi,
- Anuradha Chougule,
- Pratik Chandrani,
- Virendra Kumar Tripathi,
- Sabita Jiwnani,
- Anil Tibdewal,
- Guncha Maheshwari,
- Rushabh Kothari,
- Vijay M. Patil,
- Rajani Surendar Bhat,
- Mansi Khanderia,
- Vandana Mahajan,
- Ravi Prakash,
- Sanjeev Sharma,
- Adnan Abdul Jabbar,
- Birendra Kumar Yadav,
- A.F.M. Kamal Uddin,
- Amit Dutt,
- Kumar Prabhash
Affiliations
- Vanita Noronha
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Atul Budukh
- Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Pankaj Chaturvedi
- Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Srikanth Anne
- Department of Medical Oncology, GSL Medical College, Rajahmundry, Andhra Pradesh, India
- Anshu Punjabi
- Department of Pulmonary Medicine, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Maheema Bhaskar
- Department of Pulmonary Medicine, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Tarini P. Sahoo
- Consultant Medical Oncologist, Silverline Hospital, Bhopal, Madhya Pradesh, India
- Nandini Menon
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Minit Shah
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Ullas Batra
- Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
- Shrinidhi Nathany
- Molecular Diagnostics Section, Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
- Rajiv Kumar
- Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Omshree Shetty
- Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Trupti Pai Ghodke
- Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Abhishek Mahajan
- Department of Imaging, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK; Honorary Senior Lecturer, University of Liverpool, UK
- Nivedita Chakrabarty
- Department of Radiodiagnosis, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Supriya Hait
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment Research Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Satyendra C. Tripathi
- Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, India
- Anuradha Chougule
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Pratik Chandrani
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Virendra Kumar Tripathi
- Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Sabita Jiwnani
- Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Anil Tibdewal
- Department of Radiation Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Guncha Maheshwari
- Department of Radiation Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Rushabh Kothari
- Consultant Medical Oncologist, Oncowin Cancer Centre, Ahmedabad, India
- Vijay M. Patil
- Consultant Medical Oncologist, PD Hinduja Hospital & Medical Research Centre, Khar and Mahim, Mumbai, India
- Rajani Surendar Bhat
- Interventional Pulmonology and Palliative Medicine, Sparsh Hospitals, Bangalore, India
- Mansi Khanderia
- Department of Medical Oncology, Mazumdar Shaw Cancer Centre, Narayana Health City, Bommasandra, Bangalore, Karnataka, India
- Vandana Mahajan
- PG Integrated Counselling, Cancer Counsellor and Palliative Care Coach and Cancer Survivor, India
- Ravi Prakash
- British Broadcasting Corporation (BBC), Based in Ranchi, Jharkhand, India
- Sanjeev Sharma
- NGO Excellence Program, Patient Advocate, Lung Connect, Mumbai, India
- Adnan Abdul Jabbar
- Dr Ziauddin Hospital, Karachi, Pakistan
- Birendra Kumar Yadav
- Department of Clinical Oncology, Purbanchal Cancer Hospital, Birtamode Jhapa State, Koshi, Nepal
- A.F.M. Kamal Uddin
- Department of Radiation Oncology, National Institute of Ear Nose and Throat, Dhaka, Bangladesh
- Amit Dutt
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment Research Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India; Homi Bhabha National Institute (HBNI), Mumbai, India
- Kumar Prabhash
- Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, India; Homi Bhabha National Institute (HBNI), Mumbai, India; Corresponding author. Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Dr Ernest Borges Road, Parel, Mumbai, 400012, India.
- Journal volume & issue
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Vol. 27
p. 100430
Abstract
Summary: Lung cancer varies between Caucasians and Asians. There have been differences recorded in the epidemiology, genomics, standard therapies and outcomes, with variations according to the geography and ethnicity which affect the decision for optimal treatment of the patients. To better understand the profile of lung cancer in Southeast Asia, with a focus on India, we have comprehensively reviewed the available data, and discuss the challenges and the way forward. A substantial proportion of patients with lung cancer in Southeast Asia are neversmokers, and adenocarcinoma is the common histopathologic subtype, found in approximately a third of the patients. EGFR mutations are noted in 23–30% of patients, and ALK rearrangements are noted in 5–7%. Therapies are similar to global standards, although access to newer modalities and molecules is a challenge. Collaborative research, political will with various policy changes and patient advocacy are urgently needed.