Journal of Hematology & Oncology (Aug 2021)

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

  • Seyed Esmaeil Ahmadi,
  • Samira Rahimi,
  • Bahman Zarandi,
  • Rouzbeh Chegeni,
  • Majid Safa

DOI
https://doi.org/10.1186/s13045-021-01111-4
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 49

Abstract

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Abstract MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

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