Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO 41413
Yuxiu Ye,
Jiaqi Liang,
Jianglian She,
Xiuping Lin,
Junfeng Wang,
Yonghong Liu,
Dehua Yang,
Yanhui Tan,
Xiaowei Luo,
Xuefeng Zhou
Affiliations
Yuxiu Ye
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Jiaqi Liang
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Jianglian She
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Xiuping Lin
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Junfeng Wang
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Yonghong Liu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Dehua Yang
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Yanhui Tan
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541001, China
Xiaowei Luo
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Xuefeng Zhou
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Marine sponge-derived fungi have been proven to be a prolific source of bioactive natural products. Two new alkaloids, polonimides E (1) and D (2), and a new butenolide derivative, eutypoid F (11), were isolated from the Beibu Gulf sponge-derived fungus, Penicillium sp. SCSIO 41413, together with thirteen known compounds (3–10, 12–16). Their structures were determined by detailed NMR, MS spectroscopic analyses, and electronic circular dichroism (ECD) analyses. Butenolide derivatives 11 and 12 exhibited inhibitory effect against the enzyme PI3K with IC50 values of 1.7 μM and 9.8 μM, respectively. The molecular docking was also performed to understand the inhibitory activity, while 11 and 12 showed obvious protein/ligand-binding effects to the PI3K protein. Moreover, 4 and 15 displayed obvious inhibitory activity against LPS-induced NF-κB activation in RAW264.7 cells at 10 µM.
