Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue
Adam C. Lehnig,
Revati S. Dewal,
Lisa A. Baer,
Kathryn M. Kitching,
Vitor Rosetto Munoz,
Peter J. Arts,
Devin A. Sindeldecker,
Francis J. May,
Hans P.M.M. Lauritzen,
Laurie J. Goodyear,
Kristin I. Stanford
Affiliations
Adam C. Lehnig
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Revati S. Dewal
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Lisa A. Baer
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Kathryn M. Kitching
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Vitor Rosetto Munoz
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA; Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil
Peter J. Arts
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Devin A. Sindeldecker
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Francis J. May
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA
Hans P.M.M. Lauritzen
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, USA
Laurie J. Goodyear
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
Kristin I. Stanford
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12th Avenue, Columbus, OH 43210, USA; Corresponding author
Summary: Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, and interscapular brown adipose tissue (iBAT). Although these AT depots play important roles in metabolism, they account for only ∼50% of the AT mass in a mouse. Here, we investigated the effects of 3 weeks of exercise training on all 14 AT depots. Exercise induced depot-specific effects in genes involved in mitochondrial activity, glucose metabolism, and fatty acid uptake and oxidation in each adipose tissue (AT) depot. These data demonstrate that exercise training results in unique responses in each AT depot; identifying the depot-specific adaptations to AT in response to exercise is essential to determine how AT contributes to the overall beneficial effect of exercise. : Molecular Biology; Molecular Mechanism of Behavior; Cell Biology; Specialized Functions of Cells Subject Areas: Molecular Biology, Molecular Mechanism of Behavior, Cell Biology, Specialized Functions of Cells
