Frontiers in Endocrinology (Dec 2021)

Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study

  • Jamie van Son,
  • Sabrina M. Oussaada,
  • Aydin Şekercan,
  • Martijn Beudel,
  • Dave A. Dongelmans,
  • Sander van Assen,
  • Ingo A. Eland,
  • Hazra S. Moeniralam,
  • Tom P. J. Dormans,
  • Colin A. J. van Kalkeren,
  • Renée A. Douma,
  • Daisy Rusch,
  • Suat Simsek,
  • Suat Simsek,
  • Limmie Liu,
  • Ruud S. Kootte,
  • Caroline E. Wyers,
  • Richard G. IJzerman,
  • Joop P. van den Bergh,
  • Coen D. A. Stehouwer,
  • Max Nieuwdorp,
  • Kasper W. ter Horst,
  • Mireille J. Serlie

DOI
https://doi.org/10.3389/fendo.2021.747732
Journal volume & issue
Vol. 12

Abstract

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ObjectiveTo evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.DesignRetrospective, observational cohort study.MethodsWe performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.ResultsOut of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.ConclusionIn this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.

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