Epigenetic modifications in hematopoietic ecosystem: a key tuner from homeostasis to acute myeloid leukemia
Shuxin Yao,
Rongxia Guo,
Wen Tian,
Yanbing Zheng,
Jin Hu,
Guoqiang Han,
Rong Yin,
Fuling Zhou,
Haojian Zhang
Affiliations
Shuxin Yao
a State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Rongxia Guo
d Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
Wen Tian
a State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Yanbing Zheng
c Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China
Jin Hu
c Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China
Guoqiang Han
b Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University, Wuhan, China
Rong Yin
b Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University, Wuhan, China
Fuling Zhou
b Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University, Wuhan, China
Haojian Zhang
a State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Hematopoietic stem cells (HSCs) maintain homeostasis in the hematopoietic ecosystem, which is tightly regulated at multiple layers. Acute myeloid leukemia (AML) is a severe hematologic malignancy driven by genetic and epigenetic changes that lead to the transformation of leukemia stem cells (LSCs). Since somatic mutations in DNA methylation-related genes frequently occur in AML, DNA methylation is widely altered and functions as a starting engine for initiating AML. Additionally, RNA modifications, especially N6-methyladenosine (m6A), also play an important role in the generation and maintenance of the hematopoietic ecosystem, and AML development requires reprogramming of m6A modifications to facilitate cells with hallmarks of cancer. Given the complex pathogenesis and poor prognosis of AML, it is important to fully understand its pathogenesis. Here, we mainly focus on DNA methylation and RNA m6A modification in hematopoiesis and AML and summarize recent advances in this field.
